The Double Helix -Glass Bead DNA Model V2.0

by ChrysN in Workshop > Science

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The Double Helix -Glass Bead DNA Model V2.0

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Here is my second glass bead DNA double helix model. In this model I used wire instead of thread and I also added more space between the base pairs.

Here is a link to my first model.

Materials:

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-Five different colours of seed beads (I used glass beads).

  • one colour makes up the sugar-phosphate backbone.
  • four colours for the bases, pair up the colours so that they always appear together. (eg red-blue, green-yellow).

- ~50cm strand of jewelry wire (should be more than you need, but rather have too much than too little).

-Scissors for cutting the wire.

The First Bead

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  • The first bead will be the colour of the sugar-phosphate backbone.
  • Thread one end of the wire through the first bead, pull it through until it is in the middle of the thread. (see images below)
  • Take the other end of the wire and thread it through the bead in the opposite direction.
  • Pull ends tight.

The First Row

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  • Thread four beads (the same colour as the first bead) through each of the two wire ends (these are end spacers.)
  • Pull these through to the first bead.
  • The first row consists of 6 beads, the outer two are the same as in the previous step, which will be the sugar-phosphate backbone (dark blue), the middle beads are the base pairs; two beads of each colour in this case two yellow and two green beads. (See my colour pattern in step 5)
  • Thread one end of the wire through the six beads, pull it through to you meet up with spacer beads. (see images below)
  • Take the other end of the wire and thread it through the beads in the opposite direction.
  • Pull ends tight.

The Second Row

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  • Thread two beads (the colour of the sugar-phosphate backbone) through each of the two wire ends, these are the spacers between the base pairs.
  • Pull these through to the previous row.
  • The second row consists of 6 beads, the outer two are the same as the sugar-phosphate backbone (dark blue), the middle beads are the base pairs; two beads of each colour in this case two red and two light blue beads. (See my pattern in step 5)
  • Thread one end of the wire through the six beads, pull it through to meet up with the spacer beads. (see images below)
  • Take the other end of the wire and thread it through the beads in the opposite direction.
  • Pull ends tight.

Continuing On......

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Continue adding more rows of beads using the pattern below, with two bead spacers between the base pairs for a total of 14 rows (14bp). You can make it longer if you would like.

The colour pattern is just a suggestion, feel free to play around with the colours, just make sure you keep your base pair colours together.

You can have fun with this by assigning the colours a specific nucleotide (eg. red=Guanine, blue=Cytosine, yellow=Adenine, green=Thymine). Make your favorite amino acids, use TTAGGG repeats and call it a telomere, or copy a gene sequence (although the average human gene is 3000bp this is probably not a good idea).

Finishing Up

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  • Thread four beads (dark blue) through each of the two wire ends.
  • Pull these through to the previous row.
  • Thread one end of the wire through the last bead (again,dark blue), pull it through to meet up with spacer beads.
  • Take the other end of the wire and thread it through the bead in the opposite direction.
  • Take one of the wires and loop around and thread through the bead again, pull tight, this is to finish it off
  • Tie a knot close to the bead, then make a loop for hanging and tie another knot and cut off the excess wires.

    • Holding either end of the DNA, bend and twist to form a helix shape. (sorry I don't have pictures of this, both hands were busy bending and twisting).

The helix is similar to a corkscrew or two interlocking bedsprings, you may need to play around with the shape to get the look you want.